Can Previous Associations of Single Nucleotide Polymorphisms in the <i>TLR2</i>, <i>NOD1</i>, <i>CXCR5</i>, and <i>IL10</i> Genes in the Susceptibility to and Severity of <i>Chlamydia trachomatis</i> Infections Be Confirmed?
Jelmer B. Jukema,
Bernice M. Hoenderboom,
Birgit H. B. van Benthem,
Marianne A. B. van der Sande,
Henry J. C. de Vries,
Christian J. P. A. Hoebe,
Nicole H. T. M. Dukers-Muijrers,
Caroline J. Bax,
Servaas A. Morré,
Sander Ouburg
Affiliations
Jelmer B. Jukema
Laboratory of Immunogenetics, Department Medical Microbiology and Infection Control, Amsterdam UMC, Location AMC, 1100 DD Amsterdam, The Netherlands
Bernice M. Hoenderboom
Laboratory of Immunogenetics, Department Medical Microbiology and Infection Control, Amsterdam UMC, Location AMC, 1100 DD Amsterdam, The Netherlands
Birgit H. B. van Benthem
Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
Marianne A. B. van der Sande
Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
Henry J. C. de Vries
Amsterdam UMC, University of Amsterdam, Department of Dermatology, Amsterdam Institute for Infection and Immunity (AI&II), Location Academic Medical Centre, 1100 DD Amsterdam, The Netherlands
Christian J. P. A. Hoebe
Department of Sexual Health, Infectious Diseases and Environmental Health, South Limburg Public Health Service (GGD South Limburg), 6160 HA Geleen, The Netherlands
Nicole H. T. M. Dukers-Muijrers
Department of Sexual Health, Infectious Diseases and Environmental Health, South Limburg Public Health Service (GGD South Limburg), 6160 HA Geleen, The Netherlands
Caroline J. Bax
Department of Obstetrics and Gynaecology, Amsterdam UMC, Location AMC, University of Amsterdam, 1100 DD Amsterdam, The Netherlands
Servaas A. Morré
Laboratory of Immunogenetics, Department Medical Microbiology and Infection Control, Amsterdam UMC, Location AMC, 1100 DD Amsterdam, The Netherlands
Sander Ouburg
Laboratory of Immunogenetics, Department Medical Microbiology and Infection Control, Amsterdam UMC, Location AMC, 1100 DD Amsterdam, The Netherlands
Clear inter-individual differences exist in the response to C. trachomatis (CT) infections and reproductive tract complications in women. Host genetic variation like single nucleotide polymorphisms (SNPs) have been associated with differences in response to CT infection, and SNPs might be used as a genetic component in a tubal-pathology predicting algorithm. Our aim was to confirm the role of four genes by investigating proven associated SNPs in the susceptibility and severity of a CT infection. A total of 1201 women from five cohorts were genotyped and analyzed for TLR2 + 2477 G > A, NOD1 + 32656 T −> GG, CXCR5 + 10950 T > C, and IL10 − 1082 A > G. Results confirmed that NOD1 + 32656 T −>GG was associated with an increased risk of a symptomatic CT infection (OR: 1.9, 95%CI: 1.1–3.4, p = 0.02), but we did not observe an association with late complications. IL10 − 1082 A > G appeared to increase the risk of late complications (i.e., ectopic pregnancy/tubal factor infertility) following a CT infection (OR = 2.8, 95%CI: 1.1–7.1, p = 0.02). Other associations were not found. Confirmatory studies are important, and large cohorts are warranted to further investigate SNPs’ role in the susceptibility and severity of a CT infection.
