PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma

Tianrun Liu; Wenjuan Ma; Haineng Xu; Menggui Huang; Duo Zhang; Zhenqiang He; Lin Zhang; Steven Brem; Donald M. O’Rourke; Yanqing Gong; Yonggao Mou; Zhenfeng Zhang; Yi Fan

doi:10.1038/s41467-018-05982-z

Nature Communications (Aug 2018)

PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma

Tianrun Liu,
Wenjuan Ma,
Haineng Xu,
Menggui Huang,
Duo Zhang,
Zhenqiang He,
Lin Zhang,
Steven Brem,
Donald M. O’Rourke,
Yanqing Gong,
Yonggao Mou,
Zhenfeng Zhang,
Yi Fan

Affiliations

Tianrun Liu: Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine
Wenjuan Ma: Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine
Haineng Xu: Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine
Menggui Huang: Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine
Duo Zhang: Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine
Zhenqiang He: Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine
Lin Zhang: Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine
Steven Brem: Department of Neurosurgery, University of Pennsylvania Perelman School of Medicine
Donald M. O’Rourke: Department of Neurosurgery, University of Pennsylvania Perelman School of Medicine
Yanqing Gong: Division of Human Genetics and Translational Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine
Yonggao Mou: Department of Neurosurgery, State Key Laboratory of Oncology in South China & Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
Zhenfeng Zhang: Department of Radiology, The Second Affiliated Hospital of Guangzhou Medical University
Yi Fan: Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine

DOI: https://doi.org/10.1038/s41467-018-05982-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

Read online

Resistance to anti-angiogenic therapies often occurs in patients. Here, the authors demonstrate the role of PDGF signaling in GBM resistance to anti-VEGF treatment via a mechanism that involves endothelial-mesenchymal transformation and transcriptional regulation of VEGFR-2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal