Pyrin-only protein 2 limits inflammation but improves protection against bacteria

Sivakumar Periasamy; Kristen A. Porter; Maninjay K. Atianand; Hongnga T. Le; Sarah Earley; Ellen B. Duffy; Matthew C. Haller; Heather Chin; Jonathan A. Harton

doi:10.1038/ncomms15564

Nature Communications (Jun 2017)

Pyrin-only protein 2 limits inflammation but improves protection against bacteria

Sivakumar Periasamy,
Kristen A. Porter,
Maninjay K. Atianand,
Hongnga T. Le,
Sarah Earley,
Ellen B. Duffy,
Matthew C. Haller,
Heather Chin,
Jonathan A. Harton

Affiliations

Sivakumar Periasamy: Department of Immunology and Microbial Disease, Albany Medical College
Kristen A. Porter: Department of Immunology and Microbial Disease, Albany Medical College
Maninjay K. Atianand: Department of Immunology and Microbial Disease, Albany Medical College
Hongnga T. Le: Department of Immunology and Microbial Disease, Albany Medical College
Sarah Earley: Department of Immunology and Microbial Disease, Albany Medical College
Ellen B. Duffy: Department of Immunology and Microbial Disease, Albany Medical College
Matthew C. Haller: Department of Immunology and Microbial Disease, Albany Medical College
Heather Chin: Department of Immunology and Microbial Disease, Albany Medical College
Jonathan A. Harton: Department of Immunology and Microbial Disease, Albany Medical College

DOI: https://doi.org/10.1038/ncomms15564
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Pyrin-only proteins (POPs) are primate-specific negative regulators of inflammasome activation. Here the authors generate transgenic mice expressing POP2 under the control of the human promoter, and show that POP2 is important for balancing antibacterial inflammatory responsesin vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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