Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma

Baharan Fekry; Aleix Ribas-Latre; Corrine Baumgartner; Jonathan R. Deans; Christopher Kwok; Pooja Patel; Loning Fu; Rebecca Berdeaux; Kai Sun; Mikhail G. Kolonin; Sidney H. Wang; Seung-Hee Yoo; Frances M. Sladek; Kristin Eckel-Mahan

doi:10.1038/s41467-018-06648-6

Nature Communications (Oct 2018)

Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma

Baharan Fekry,
Aleix Ribas-Latre,
Corrine Baumgartner,
Jonathan R. Deans,
Christopher Kwok,
Pooja Patel,
Loning Fu,
Rebecca Berdeaux,
Kai Sun,
Mikhail G. Kolonin,
Sidney H. Wang,
Seung-Hee Yoo,
Frances M. Sladek,
Kristin Eckel-Mahan

Affiliations

Baharan Fekry: Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)
Aleix Ribas-Latre: Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)
Corrine Baumgartner: Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)
Jonathan R. Deans: Department of Molecular, Cell and Systems Biology, University of California Riverside
Christopher Kwok: Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)
Pooja Patel: Department of Pediatrics, Molecular and Cellular Biology, Children’s Nutrition Research Center, Baylor College of Medicine
Loning Fu: Department of Pediatrics, Molecular and Cellular Biology, Children’s Nutrition Research Center, Baylor College of Medicine
Rebecca Berdeaux: Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)
Kai Sun: Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)
Mikhail G. Kolonin: Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)
Sidney H. Wang: Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)
Seung-Hee Yoo: Department of Biochemistry and Molecular Biology, McGovern Medical School at the University of Texas Health Science Center (UT Health)
Frances M. Sladek: Department of Molecular, Cell and Systems Biology, University of California Riverside
Kristin Eckel-Mahan: Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)

DOI: https://doi.org/10.1038/s41467-018-06648-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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Hepatocyte nuclear factor 4 alpha (HNF4α) is regulated by different promoters to generate two isoforms, one of which functions as a tumor suppressor. Here, the authors reveal that induction of the alternative isoform in hepatocellular carcinoma inhibits the circadian clock by repressing BMAL1, and the reintroduction of BMAL1 prevents HCC tumor growth.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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