Nature Communications (Dec 2017)
A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning
- Carina Fischer,
- Takahiro Seki,
- Sharon Lim,
- Masaki Nakamura,
- Patrik Andersson,
- Yunlong Yang,
- Jennifer Honek,
- Yangang Wang,
- Yanyan Gao,
- Fang Chen,
- Nilesh J. Samani,
- Jun Zhang,
- Masato Miyake,
- Seiichi Oyadomari,
- Akihiro Yasue,
- Xuri Li,
- Yun Zhang,
- Yizhi Liu,
- Yihai Cao
Affiliations
- Carina Fischer
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Takahiro Seki
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Sharon Lim
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Masaki Nakamura
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Patrik Andersson
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Yunlong Yang
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Jennifer Honek
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Yangang Wang
- Department of Endocrinology, Affiliated Hospital of Qingdao University
- Yanyan Gao
- Department of Endocrinology, Affiliated Hospital of Qingdao University
- Fang Chen
- Hospital of Zhejiang Chinese Medicine University
- Nilesh J. Samani
- Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital
- Jun Zhang
- Division of Molecular Biology, Institute for Genome Research, Institute of Advanced Medical Sciences, Tokushima University
- Masato Miyake
- Division of Molecular Biology, Institute for Genome Research, Institute of Advanced Medical Sciences, Tokushima University
- Seiichi Oyadomari
- Division of Molecular Biology, Institute for Genome Research, Institute of Advanced Medical Sciences, Tokushima University
- Akihiro Yasue
- Department of Orthodontics Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School
- Xuri Li
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University
- Yun Zhang
- The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University Qilu Hospital
- Yizhi Liu
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University
- Yihai Cao
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- DOI
- https://doi.org/10.1038/s41467-017-02158-z
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 19
Abstract
White adipocytes can be stimulated to express thermogenic genes in a process known as beiging. Here, the authors show that miR-327 is downregulated during beiging, which releases FGF10 from inhibition and supports beige adipocyte formation via signaling through FGFR2.
