Endocrine Regulations (Apr 2021)

ERN1 knockdown modifies the impact of glucose and glutamine deprivations on the expression of EDN1 and its receptors in glioma cells

  • Minchenko Dmytro O.,
  • Khita Olena O.,
  • Tsymbal Dariia O.,
  • Viletska Yuliia M.,
  • Sliusar Myroslava Y.,
  • Yefimova Yuliia V.,
  • Levadna Liudmyla O.,
  • Krasnytska Dariia A.,
  • Minchenko Oleksandr H.

DOI
https://doi.org/10.2478/enr-2021-0009
Journal volume & issue
Vol. 55, no. 2
pp. 72 – 82

Abstract

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Objective. The aim of the present investigation was to study the impact of glucose and gluta-mine deprivations on the expression of genes encoding EDN1 (endothelin-1), its cognate receptors (EDNRA and EDNRB), and ECE1 (endothelin converting enzyme 1) in U87 glioma cells in response to knockdown of ERN1 (endoplasmic reticulum to nucleus signaling 1), a major signaling pathway of endoplasmic reticulum stress, for evaluation of their possible implication in the control of glioma growth through ERN1 and nutrient limitations.

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