Frontiers in Immunology (May 2022)
Gut Dysbiosis Is Associated With the Severity of Cryptogenic Stroke and Enhanced Systemic Inflammatory Response
- Qianyi Zheng,
- Qianyi Zheng,
- Yongkang Chen,
- Yongkang Chen,
- Yanping Zhai,
- Yanping Zhai,
- Lin Meng,
- Lin Meng,
- Han Liu,
- Han Liu,
- Haiyan Tian,
- Haiyan Tian,
- Renyi Feng,
- Renyi Feng,
- Jiuqi Wang,
- Jiuqi Wang,
- Rui Zhang,
- Rui Zhang,
- Kedi Sun,
- Kedi Sun,
- Lina Gao,
- Lina Gao,
- Yijing Wang,
- Yijing Wang,
- Xuejing Wang,
- Xuejing Wang,
- Erxi Wu,
- Erxi Wu,
- Erxi Wu,
- Erxi Wu,
- Junfang Teng,
- Junfang Teng,
- Xuebing Ding,
- Xuebing Ding
Affiliations
- Qianyi Zheng
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Qianyi Zheng
- Institute of Parkinson and Movement Disorder, Zhengzhou University, Zhengzhou, China
- Yongkang Chen
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yongkang Chen
- Institute of Parkinson and Movement Disorder, Zhengzhou University, Zhengzhou, China
- Yanping Zhai
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yanping Zhai
- Institute of Parkinson and Movement Disorder, Zhengzhou University, Zhengzhou, China
- Lin Meng
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Lin Meng
- Institute of Parkinson and Movement Disorder, Zhengzhou University, Zhengzhou, China
- Han Liu
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Han Liu
- Institute of Parkinson and Movement Disorder, Zhengzhou University, Zhengzhou, China
- Haiyan Tian
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Haiyan Tian
- Institute of Parkinson and Movement Disorder, Zhengzhou University, Zhengzhou, China
- Renyi Feng
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Renyi Feng
- Institute of Parkinson and Movement Disorder, Zhengzhou University, Zhengzhou, China
- Jiuqi Wang
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Jiuqi Wang
- Institute of Parkinson and Movement Disorder, Zhengzhou University, Zhengzhou, China
- Rui Zhang
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Rui Zhang
- Institute of Parkinson and Movement Disorder, Zhengzhou University, Zhengzhou, China
- Kedi Sun
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Kedi Sun
- Institute of Parkinson and Movement Disorder, Zhengzhou University, Zhengzhou, China
- Lina Gao
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Lina Gao
- Institute of Parkinson and Movement Disorder, Zhengzhou University, Zhengzhou, China
- Yijing Wang
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yijing Wang
- Institute of Parkinson and Movement Disorder, Zhengzhou University, Zhengzhou, China
- Xuejing Wang
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Xuejing Wang
- Institute of Parkinson and Movement Disorder, Zhengzhou University, Zhengzhou, China
- Erxi Wu
- Neuroscience Institute and Department of Neurosurgery, Baylor Scott & White Health, Temple, TX, United States
- Erxi Wu
- College of Medicine, Texas A&M University, College Station, TX, United States
- Erxi Wu
- Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, TX, United States
- Erxi Wu
- LIVESTRONG Cancer Institutes and Department of Oncology, Dell Medical School, University of Texas at Austin, Austin, TX, United States
- Junfang Teng
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Junfang Teng
- Institute of Parkinson and Movement Disorder, Zhengzhou University, Zhengzhou, China
- Xuebing Ding
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Xuebing Ding
- Institute of Parkinson and Movement Disorder, Zhengzhou University, Zhengzhou, China
- DOI
- https://doi.org/10.3389/fimmu.2022.836820
- Journal volume & issue
-
Vol. 13
Abstract
Studies implicate that gut dysbiosis is related with many neurological diseases. However, the potential role of gut dysbiosis in cryptogenic stroke (CS) has not been elucidated yet. In this study, a high prevalence of gastrointestinal (GI) dysfunction and gut inflammation with increased intestinal permeability have been found in CS patients compared with normal controls (NCs). The systemic inflammation in CS patients was also identified by measuring the levels of plasma C-reactive protein (CRP), lipopolysaccharide (LPS), LPS-binding protein (LBP), and white blood cells (WBC) count. Using 16S rRNA sequencing, we found increased alpha diversity, accompanied by a higher abundance of Enterobacteriaceae, Streptococcaceae, and Lactobacillaceae at the family level and Escherichia–Shigella, Streptococcus, Lactobacillus, and Klebsilla at the genus level in the intestinal microbiota of CS patients compared to NCs. Our results showed that the abundance of Klebsilla was positively correlated with the systemic inflammation, the National Institutes of Health Stroke Scale (NIHSS) scores, and the infarct volumes. In conclusion, gut dysbiosis in CS patients was associated with the severity of CS and the systemic inflammation. Maintaining the intestinal homeostasis may be a potential strategy for the treatment of CS.
Keywords
