Measuring the level of IL-4 and IL-25 in the serum of eczema patients

Abstract

Eczema is an inflammatory skin disease and may be the result of environmental factors, genetic factors, and immune factors. Itching, persistent scratching, skin redness, and dryness are the primary signs of the illness. Many Cytokines are essential to the pathophysiology of disease, including the role of interleukin-4 and interleukin-25 as major players in the immune pathogenesis of eczema. This study was conducted with the aim of evaluating some seromic criteria that clarify the effect of some immune and inflammatory factors on the pathological condition in eczema patients and comparing them with the healthy group. This can help determine whether there is a relationship between the level of interleukin-4 and the high level of interleukin-25 and the clinical symptoms of the disease. The current study was conducted in Marjan Medical City in Babylon Governorate. Samples of (50) patients with eczema were collected after being diagnosed by dermatologists, and samples of (50) ostensibly healthy people were collected as a control group. The enzyme-associated immuno-absorption method (Elisa) was used to measure the level of interleukin-4 and interleukin-25 in the serum of all patients and the control group Serum levels of interleukin-4 and interleukin-25 are significantly higher in eczema patients at the probability level (P <0.05), while they decrease in the control group for the same criteria rates According to the results of the current investigation, patients with eczema reported higher levels of interleukin-4 and interleukin-25 in the serum than the control group.

Keywords

• cytokines
• interleukin-4
• interleukin-25
• inflammatory factors