Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control

Yavuz Kulaberoglu; Kui Lin; Maxine Holder; Zhongchao Gai; Marta Gomez; Belul Assefa Shifa; Merdiye Mavis; Lily Hoa; Ahmad A. D. Sharif; Celia Lujan; Ewan St. John Smith; Ivana Bjedov; Nicolas Tapon; Geng Wu; Alexander Hergovich

doi:10.1038/s41467-017-00795-y

Nature Communications (Sep 2017)

Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control

Yavuz Kulaberoglu,
Kui Lin,
Maxine Holder,
Zhongchao Gai,
Marta Gomez,
Belul Assefa Shifa,
Merdiye Mavis,
Lily Hoa,
Ahmad A. D. Sharif,
Celia Lujan,
Ewan St. John Smith,
Ivana Bjedov,
Nicolas Tapon,
Geng Wu,
Alexander Hergovich

Affiliations

Yavuz Kulaberoglu: Tumour Suppressor Signalling Network Laboratory, UCL Cancer Institute, University College London
Kui Lin: State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University
Maxine Holder: Apoptosis and Proliferation Control Laboratory, Francis Crick Institute
Zhongchao Gai: State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University
Marta Gomez: Tumour Suppressor Signalling Network Laboratory, UCL Cancer Institute, University College London
Belul Assefa Shifa: Tumour Suppressor Signalling Network Laboratory, UCL Cancer Institute, University College London
Merdiye Mavis: Tumour Suppressor Signalling Network Laboratory, UCL Cancer Institute, University College London
Lily Hoa: Tumour Suppressor Signalling Network Laboratory, UCL Cancer Institute, University College London
Ahmad A. D. Sharif: Tumour Suppressor Signalling Network Laboratory, UCL Cancer Institute, University College London
Celia Lujan: Molecular Biology of Cancer laboratory, UCL Cancer Institute, University College London
Ewan St. John Smith: Department of Pharmacology, University of Cambridge
Ivana Bjedov: Molecular Biology of Cancer laboratory, UCL Cancer Institute, University College London
Nicolas Tapon: Apoptosis and Proliferation Control Laboratory, Francis Crick Institute
Geng Wu: State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University
Alexander Hergovich: Tumour Suppressor Signalling Network Laboratory, UCL Cancer Institute, University College London

DOI: https://doi.org/10.1038/s41467-017-00795-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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The Hippo tumor suppressor pathway is essential for development and tissue growth control. Here the authors employ a multi-disciplinary approach to characterize the interactions of the three Hippo kinases with the signaling adaptor MOB1 and show how they differently affect development, tissue growth and tumor suppression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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