A Common Approach to the Synthesis of Monocyclofarnesyl Sesquiterpenes

Abstract

3beta-hydroxy-4,4,10beta-trimethyl-9-decalone and its dehydroxy analogue are useful intermediates whose Baeyer-Villiger oxidation and subsequent two-carbon homologation provides a quick entry into the monocyclofarnesyl skeleton. The synthetic approaches to a variety of sesquiterpenes are discussed.

Keywords

• Baeyer-Villiger reaction
• monocyclofarnesyl
• sesquiterpenes
• aplysistatin
• ambilol
• 7-hydroxy-6,11-cyclofarnes-3(15)-en-2-one
• ancistrofuran
• synthesis