IL-1-dependent enteric gliosis guides intestinal inflammation and dysmotility and modulates macrophage function

Affiliations

Reiner Schneider: Department of Surgery, University Hospital Bonn
Patrick Leven: Department of Surgery, University Hospital Bonn
Shilpashree Mallesh: Department of Surgery, University Hospital Bonn
Mona Breßer: Department of Surgery, University Hospital Bonn
Linda Schneider: Department of Surgery, University Hospital Bonn
Elvio Mazzotta: Department of Anesthesiology, Wexner Medical Center, The Ohio State University
Paola Fadda: Department of Anesthesiology, Wexner Medical Center, The Ohio State University
Tim Glowka: Department of Surgery, University Hospital Bonn
Tim O. Vilz: Department of Surgery, University Hospital Bonn
Philipp Lingohr: Department of Surgery, University Hospital Bonn
Jörg C. Kalff: Department of Surgery, University Hospital Bonn
Fievos L. Christofi: Department of Anesthesiology, Wexner Medical Center, The Ohio State University
Sven Wehner: Department of Surgery, University Hospital Bonn

Abstract

IL1R1-signaling triggers enteric glia reactivity, resulting in enteric gliosis, macrophage activation and the development of postoperative ileus.