Química Nova (Oct 2001)

Proposição, validação e análise dos modelos que correlacionam estrutura química e atividade biológica Proposition, validation and analysis of QSAR models

  • Anderson Coser Gaudio,
  • Eliana Zandonade

DOI
https://doi.org/10.1590/S0100-40422001000500013
Journal volume & issue
Vol. 24, no. 5
pp. 658 – 671

Abstract

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The present paper aims to bring under discussion some theoretical and practical aspects about the proposition, validation and analysis of QSAR models based on multiple linear regression. A comprehensive approach for the derivation of extrathermodynamic equations is reviewed. Some examples of QSAR models published in the literature are analyzed and criticized.

Keywords