Sustained delivery of osteogenic growth peptide through injectable photoinitiated composite hydrogel for osteogenesis

Beibei Liu; Beibei Liu; Jiannan Wu; Jiannan Wu; Xiaodi Sun; Xiaodi Sun; Qingxun Meng; Qingxun Meng; Jian Zhang; Jian Zhang

doi:10.3389/fbioe.2023.1228250

Frontiers in Bioengineering and Biotechnology (Aug 2023)

Sustained delivery of osteogenic growth peptide through injectable photoinitiated composite hydrogel for osteogenesis

Beibei Liu,
Beibei Liu,
Jiannan Wu,
Jiannan Wu,
Xiaodi Sun,
Xiaodi Sun,
Qingxun Meng,
Qingxun Meng,
Jian Zhang,
Jian Zhang

Affiliations

Beibei Liu: Department of Oral Implantology, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China
Beibei Liu: Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China
Jiannan Wu: Department of Oral Implantology, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China
Jiannan Wu: Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China
Xiaodi Sun: Department of Oral Implantology, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China
Xiaodi Sun: Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China
Qingxun Meng: Department of Oral Implantology, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China
Qingxun Meng: Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China
Jian Zhang: Department of Oral Implantology, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China
Jian Zhang: Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China

DOI: https://doi.org/10.3389/fbioe.2023.1228250
Journal volume & issue: Vol. 11

Abstract

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One of the most challenging clinical issues continues to be the effective bone regeneration and rebuilding following bone abnormalities. Although osteogenic growth peptide (OGP) has been proven to be effective in promoting osteoblast activity, its clinical application is constrained by abrupt release and easily degradation. We developed a GelMA/HAMA dual network hydrogel loaded with OGP based on a combination of physical chain entanglement and chemical cross-linking effects to produce an efficient long-term sustained release of OGP. The hydrogel polymers were quickly molded under ultraviolet (UV) light and had the suitable physical characteristics, porosity structure and biocompatibility. Significantly, the GelMA/HAMA-OGP hydrogel could promote cell proliferation, adhesion, increase osteogenic-related gene and protein expression in vitro. In conclusion, the OGP sustained-release system based on GelMA/HAMA dual network hydrogel offers a fresh perspective on bone regeneration therapy.

Published in Frontiers in Bioengineering and Biotechnology

ISSN: 2296-4185 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology
Website: http://www.frontiersin.org/bioengineering_and_biotechnology

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