A genome-wide association study for allergen component sensitizations identifies allergen component–specific and allergen protein group–specific associations

Wataru Morii, PhD; Koki Kasai, BS; Takako Nakamura, MSc; Daisuke Hayashi, MD; Monami Hara, MD; Tatsuhiko Naito, MD, PhD; Kyuto Sonehara, MD, PhD; Tatsuki Fukuie, MD, PhD; Mayako Saito-Abe, MD, PhD; Limin Yang, MD, PhD; Kiwako Yamamoto-Hanada, MD, PhD; Masami Narita, MD, PhD; Kazushi Maruo, PhD; Yukinori Okada, MD, PhD; Emiko Noguchi, MD, PhD; Yukihiro Ohya, MD, PhD

Journal of Allergy and Clinical Immunology: Global (May 2023)

A genome-wide association study for allergen component sensitizations identifies allergen component–specific and allergen protein group–specific associations

Wataru Morii, PhD,
Koki Kasai, BS,
Takako Nakamura, MSc,
Daisuke Hayashi, MD,
Monami Hara, MD,
Tatsuhiko Naito, MD, PhD,
Kyuto Sonehara, MD, PhD,
Tatsuki Fukuie, MD, PhD,
Mayako Saito-Abe, MD, PhD,
Limin Yang, MD, PhD,
Kiwako Yamamoto-Hanada, MD, PhD,
Masami Narita, MD, PhD,
Kazushi Maruo, PhD,
Yukinori Okada, MD, PhD,
Emiko Noguchi, MD, PhD,
Yukihiro Ohya, MD, PhD

Affiliations

Wataru Morii, PhD: Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Koki Kasai, BS: Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Takako Nakamura, MSc: Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Daisuke Hayashi, MD: Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Monami Hara, MD: Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Tatsuhiko Naito, MD, PhD: Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan
Kyuto Sonehara, MD, PhD: Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan
Tatsuki Fukuie, MD, PhD: Allergy Center, National Center for Child Health and Development, Tokyo, Japan
Mayako Saito-Abe, MD, PhD: Allergy Center, National Center for Child Health and Development, Tokyo, Japan
Limin Yang, MD, PhD: Allergy Center, National Center for Child Health and Development, Tokyo, Japan
Kiwako Yamamoto-Hanada, MD, PhD: Allergy Center, National Center for Child Health and Development, Tokyo, Japan
Masami Narita, MD, PhD: Allergy Center, National Center for Child Health and Development, Tokyo, Japan; Department of Pediatrics, School of Medicine, Kyorin University, Tokyo, Japan
Kazushi Maruo, PhD: Department of Biostatistics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Yukinori Okada, MD, PhD: Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan; Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Japan
Emiko Noguchi, MD, PhD: Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; Corresponding author: Emiko Noguchi, MD, PhD, Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Yukihiro Ohya, MD, PhD: Allergy Center, National Center for Child Health and Development, Tokyo, Japan

Journal volume & issue: Vol. 2, no. 2
p. 100086

Abstract

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Background: Allergic diseases are some of the most common diseases worldwide. Genome-wide association studies (GWASs) have been conducted to elucidate the genetic factors of allergic diseases. However, no GWASs for allergen component sensitization have been performed. Objective: We sought to detect genetic variants associated with differences in immune responsiveness against allergen components. Methods: The participants of the present study were recruited from the Tokyo Children’s Health, Illness, and Development study, and allergen component–specific IgE level at age 9 years was measured by means of allergen microarray immunoassays. We performed GWASs for allergen component sensitization against each allergen (single allergen component sensitization, number of allergen components analyzed, n = 31), as well as against allergen protein families (allergen protein group sensitization, number of protein groups analyzed, n = 16). Results: We performed GWAS on 564 participants of the Tokyo Children’s Health, Illness, and Development study and found associations between Amb a 1 sensitization and the immunoglobulin heavy-chain variable gene on chromosome 14 and between Phl p 1 sensitization and the HLA class II region on chromosome 6 (P < 5.0 × 10−8). A GWAS-significant association was also observed between the HLA class II region and profilin sensitization (P < 5.0 × 10−8). Conclusions: Our data provide the first demonstration of genetic risk for allergen component sensitization and show that this genetic risk is related to immune response genes including immunoglobulin heavy-chain variable gene and HLA.

Published in Journal of Allergy and Clinical Immunology: Global

ISSN: 2772-8293 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/journal-of-allergy-and-clinical-immunology-global

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