Communications Biology (Feb 2021)

Unraveling the deep learning gearbox in optical coherence tomography image segmentation towards explainable artificial intelligence

  • Peter M. Maloca,
  • Philipp L. Müller,
  • Aaron Y. Lee,
  • Adnan Tufail,
  • Konstantinos Balaskas,
  • Stephanie Niklaus,
  • Pascal Kaiser,
  • Susanne Suter,
  • Javier Zarranz-Ventura,
  • Catherine Egan,
  • Hendrik P. N. Scholl,
  • Tobias K. Schnitzer,
  • Thomas Singer,
  • Pascal W. Hasler,
  • Nora Denk

DOI
https://doi.org/10.1038/s42003-021-01697-y
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 12

Abstract

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Maloca et al. implement convolutional neural network (CNN) to automatically segment OCT images obtained from cynomolgus monkeys. The results are compared to annotations generated by human graders. The ambiguity in ground truth had noteworthy impact on machine learning results, which could be visualized.