Communications Biology (Mar 2022)

Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity

  • Dapeng Li,
  • Simon Brackenridge,
  • Lucy C. Walters,
  • Olivia Swanson,
  • Karl Harlos,
  • Daniel Rozbesky,
  • Derek W. Cain,
  • Kevin Wiehe,
  • Richard M. Scearce,
  • Maggie Barr,
  • Zekun Mu,
  • Robert Parks,
  • Max Quastel,
  • Robert J. Edwards,
  • Yunfei Wang,
  • Wes Rountree,
  • Kevin O. Saunders,
  • Guido Ferrari,
  • Persephone Borrow,
  • E. Yvonne Jones,
  • S. Munir Alam,
  • Mihai L. Azoitei,
  • Geraldine M. Gillespie,
  • Andrew J. McMichael,
  • Barton F. Haynes

DOI
https://doi.org/10.1038/s42003-022-03183-5
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 17

Abstract

Read online

The identification and structural analysis of HLA-E-VL9-targeting antibodies that block a natural killer (NK) cell receptor pathway and regulate NK function in vitro.