Nature Communications (May 2021)

MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells

  • Qiaozhi Wei,
  • Sandra Pinho,
  • Shuxian Dong,
  • Halley Pierce,
  • Huihui Li,
  • Fumio Nakahara,
  • Jianing Xu,
  • Chunliang Xu,
  • Philip E. Boulais,
  • Dachuan Zhang,
  • Maria Maryanovich,
  • Ana Maria Cuervo,
  • Paul S. Frenette

DOI
https://doi.org/10.1038/s41467-021-22749-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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Haematopoietic stem cells (HSCs) are metabolically quiescent, with balanced myeloid and lymphoid potential. Here the authors show that MAEA is required in HSCs for ubiquitination and downregulation of surface cytokine receptors via autophagy; MAEA loss leads to impaired HSC quiescence and a myeloproliferative disorder.