Cancer Immunology, Immunotherapy (Feb 2025)

Dynamic roles of tumor-infiltrating B lymphocytes in cancer immunotherapy

  • Shishengnan Song,
  • Chong Wang,
  • Yangchao Chen,
  • Xiaorong Zhou,
  • Yi Han,
  • Haijian Zhang

DOI
https://doi.org/10.1007/s00262-024-03936-7
Journal volume & issue
Vol. 74, no. 3
pp. 1 – 15

Abstract

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Abstract The amazing diversity of B cells within the tumor microenvironment is the basis for the diverse development of B cell-based immunotherapies. Here, we focus on elucidating the mechanisms of tumor intervention mediated by four tumor-infiltrating B lymphocytes. Naive B cells present the initial antigen, germinal center B cell subsets enhance antibody affinity, and immunoglobulin subtypes exert multiple immune effects, while regulatory B cells establish immune tolerance. Together they reflect the complexity of the changing dynamics of cancer immunity. Additionally, we have investigated the dynamic effects of tumor-infiltrating B lymphocytes in immunotherapy and their relationship to prognosis, providing new insights into potential treatment strategies for patients.

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