Placental multi-omics integration identifies candidate functional genes for birthweight

Fasil Tekola-Ayele; Xuehuo Zeng; Suvo Chatterjee; Marion Ouidir; Corina Lesseur; Ke Hao; Jia Chen; Markos Tesfaye; Carmen J. Marsit; Tsegaselassie Workalemahu; Ronald Wapner

doi:10.1038/s41467-022-30007-1

Nature Communications (May 2022)

Placental multi-omics integration identifies candidate functional genes for birthweight

Fasil Tekola-Ayele,
Xuehuo Zeng,
Suvo Chatterjee,
Marion Ouidir,
Corina Lesseur,
Ke Hao,
Jia Chen,
Markos Tesfaye,
Carmen J. Marsit,
Tsegaselassie Workalemahu,
Ronald Wapner

Affiliations

Fasil Tekola-Ayele: Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
Xuehuo Zeng: Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
Suvo Chatterjee: Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
Marion Ouidir: Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
Corina Lesseur: Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai
Ke Hao: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Jia Chen: Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai
Markos Tesfaye: Section of Sensory Science and Metabolism (SenSMet), National Institute on Alcohol Abuse and Alcoholism & National Institute of Nursing Research, National Institutes of Health
Carmen J. Marsit: Gangarosa Department of Environmental Health, Rollins School of Public Health of Emory University
Tsegaselassie Workalemahu: Department of Obstetrics and Gynecology, Maternal-Fetal Medicine, University of Utah
Ronald Wapner: Department of Obstetrics and Gynecology, Columbia University

DOI: https://doi.org/10.1038/s41467-022-30007-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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The placenta plays key roles in fetal development and subsequent health. Here, the authors integrate placental methylation and transcriptome data with genetic loci associated with birthweight to identify functional genes underpinning fetal growth regulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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