CREB controls cortical circuit plasticity and functional recovery after stroke

L. Caracciolo; M. Marosi; J. Mazzitelli; S. Latifi; Y. Sano; L. Galvan; R. Kawaguchi; S. Holley; M. S. Levine; G. Coppola; C. Portera-Cailliau; A. J. Silva; S. T. Carmichael

doi:10.1038/s41467-018-04445-9

Nature Communications (Jun 2018)

CREB controls cortical circuit plasticity and functional recovery after stroke

L. Caracciolo,
M. Marosi,
J. Mazzitelli,
S. Latifi,
Y. Sano,
L. Galvan,
R. Kawaguchi,
S. Holley,
M. S. Levine,
G. Coppola,
C. Portera-Cailliau,
A. J. Silva,
S. T. Carmichael

Affiliations

L. Caracciolo: Department of Neurology, David Geffen School of Medicine, University of California Los Angeles
M. Marosi: Department of Neurology, David Geffen School of Medicine, University of California Los Angeles
J. Mazzitelli: Department of Neurology, David Geffen School of Medicine, University of California Los Angeles
S. Latifi: Department of Neurology, David Geffen School of Medicine, University of California Los Angeles
Y. Sano: Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles
L. Galvan: Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles
R. Kawaguchi: Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles
S. Holley: Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles
M. S. Levine: Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles
G. Coppola: Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles
C. Portera-Cailliau: Department of Neurology, David Geffen School of Medicine, University of California Los Angeles
A. J. Silva: Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles
S. T. Carmichael: Department of Neurology, David Geffen School of Medicine, University of California Los Angeles

DOI: https://doi.org/10.1038/s41467-018-04445-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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Increasing excitability in the peri-infarct area enhances motor recovery after stroke. Here the authors show that expressing CREB, a transcription factor known for its role in synaptic plasticity, or increasing activity of CREB-expressing cells near the stroke site improves recovery in an effect that is strong enough that it can be used to turn on and off motor recovery after stroke.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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