Nature Communications (Jun 2016)
The genetic regulatory signature of type 2 diabetes in human skeletal muscle
- Laura J. Scott,
- Michael R. Erdos,
- Jeroen R. Huyghe,
- Ryan P. Welch,
- Andrew T. Beck,
- Brooke N. Wolford,
- Peter S. Chines,
- John P. Didion,
- Narisu Narisu,
- Heather M. Stringham,
- D. Leland Taylor,
- Anne U. Jackson,
- Swarooparani Vadlamudi,
- Lori L. Bonnycastle,
- Leena Kinnunen,
- Jouko Saramies,
- Jouko Sundvall,
- Ricardo D'Oliveira Albanus,
- Anna Kiseleva,
- John Hensley,
- Gregory E. Crawford,
- Hui Jiang,
- Xiaoquan Wen,
- Richard M. Watanabe,
- Timo A. Lakka,
- Karen L. Mohlke,
- Markku Laakso,
- Jaakko Tuomilehto,
- Heikki A. Koistinen,
- Michael Boehnke,
- Francis S. Collins,
- Stephen C. J. Parker
Affiliations
- Laura J. Scott
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Michael R. Erdos
- National Human Genome Research Institute, National Institutes of Health
- Jeroen R. Huyghe
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Ryan P. Welch
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Andrew T. Beck
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Brooke N. Wolford
- National Human Genome Research Institute, National Institutes of Health
- Peter S. Chines
- National Human Genome Research Institute, National Institutes of Health
- John P. Didion
- National Human Genome Research Institute, National Institutes of Health
- Narisu Narisu
- National Human Genome Research Institute, National Institutes of Health
- Heather M. Stringham
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- D. Leland Taylor
- National Human Genome Research Institute, National Institutes of Health
- Anne U. Jackson
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Swarooparani Vadlamudi
- Department of Genetics, University of North Carolina
- Lori L. Bonnycastle
- National Human Genome Research Institute, National Institutes of Health
- Leena Kinnunen
- Department of Health, National Institute for Health and Welfare
- Jouko Saramies
- South Karelia Central Hospital
- Jouko Sundvall
- Department of Health, National Institute for Health and Welfare
- Ricardo D'Oliveira Albanus
- Department of Computational Medicine & Bioinformatics, University of Michigan
- Anna Kiseleva
- Department of Computational Medicine & Bioinformatics, University of Michigan
- John Hensley
- Department of Computational Medicine & Bioinformatics, University of Michigan
- Gregory E. Crawford
- Center for Genomic & Computational Biology, Duke University
- Hui Jiang
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Xiaoquan Wen
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Richard M. Watanabe
- Department of Preventive Medicine, Keck School of Medicine of USC
- Timo A. Lakka
- Institute of Biomedicine/Physiology, University of Eastern Finland
- Karen L. Mohlke
- Department of Genetics, University of North Carolina
- Markku Laakso
- Department of Medicine, University of Eastern Finland
- Jaakko Tuomilehto
- Chronic Disease Prevention Unit, National Institute for Health and Welfare
- Heikki A. Koistinen
- Department of Health, National Institute for Health and Welfare
- Michael Boehnke
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Francis S. Collins
- National Human Genome Research Institute, National Institutes of Health
- Stephen C. J. Parker
- Department of Computational Medicine & Bioinformatics, University of Michigan
- DOI
- https://doi.org/10.1038/ncomms11764
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
More than 90% of genetic variants associated with type 2 diabetes occur in non-coding regions. Scott et al. report genomes, epigenomes and transcriptomes of skeletal muscle from 271 participants with a range of glucose tolerances, revealing a genetic regulatory architecture enriched in muscle stretch/super enhancers.
