Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine as Inhibitors of β-Glucuronidase Efficacy

Abstract

Water-soluble complexes of N-vinylpyrrolidone/N-vinylamine copolymers with lactones of D-glucuronic acid were obtained and characterized by chromatographic, spectral, and hydrodynamic methods. The complexes efficiently inhibited the enzyme β-glucuronidase that causes the appearance of bladder tumors. The products demonstrated prolonged action and were stable during storage.

Keywords

• water-soluble copolymers
• N-vinylpyrrolidone/N-vinylamine
• lactones of D-glucuronic acid
• bladder tumor
• polymer complexes of glucarolactones
• inhibition of β-glucuronidase