Nature Communications (Mar 2018)
Circular DNA elements of chromosomal origin are common in healthy human somatic tissue
Abstract
Somatic cells can accumulate structural variations such as deletions. Here, Møller et al. show that normal human cells generate large extrachromosomal circular DNAs (eccDNAs), most likely the products of excised DNA, that can be transcriptionally active and, thus, may have phenotypic consequences.