Nature Communications (Mar 2018)

Circular DNA elements of chromosomal origin are common in healthy human somatic tissue

  • Henrik Devitt Møller,
  • Marghoob Mohiyuddin,
  • Iñigo Prada-Luengo,
  • M. Reza Sailani,
  • Jens Frey Halling,
  • Peter Plomgaard,
  • Lasse Maretty,
  • Anders Johannes Hansen,
  • Michael P. Snyder,
  • Henriette Pilegaard,
  • Hugo Y. K. Lam,
  • Birgitte Regenberg

DOI
https://doi.org/10.1038/s41467-018-03369-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Somatic cells can accumulate structural variations such as deletions. Here, Møller et al. show that normal human cells generate large extrachromosomal circular DNAs (eccDNAs), most likely the products of excised DNA, that can be transcriptionally active and, thus, may have phenotypic consequences.