Modification of a Carboxymethyl Cellulose/Poly(vinyl alcohol) Hydrogel Film with Citric Acid and Glutaraldehyde Crosslink Agents to Enhance the Anti-Inflammatory Effectiveness of Triamcinolone Acetonide in Wound Healing
Kanticha Pratinthong,
Winita Punyodom,
Pensak Jantrawut,
Kittisak Jantanasakulwong,
Wirongrong Tongdeesoontorn,
Montira Sriyai,
Rangsan Panyathip,
Sarinthip Thanakkasaranee,
Patnarin Worajittiphon,
Nuttapol Tanadchangsaeng,
Pornchai Rachtanapun
Affiliations
Kanticha Pratinthong
Division of Packaging Technology, School of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand
Winita Punyodom
Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
Pensak Jantrawut
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Muang, Chiang Mai 50200, Thailand
Kittisak Jantanasakulwong
Division of Packaging Technology, School of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand
Wirongrong Tongdeesoontorn
School of Agro-Industry, Mae Fah Luang University, 333 Moo 1 Tasud, Chiang Rai 57100, Thailand
Montira Sriyai
Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand
Rangsan Panyathip
Division of Packaging Technology, School of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand
Sarinthip Thanakkasaranee
Division of Packaging Technology, School of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand
Patnarin Worajittiphon
Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
Nuttapol Tanadchangsaeng
College of Biomedical Engineering, Rangsit University, Pathumthani 12000, Thailand
Pornchai Rachtanapun
Division of Packaging Technology, School of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand
Anti-inflammatory wound healing involves targeted drug delivery to the wound site using hydrogel materials to prolong drug effectiveness. In this work, hydrogel films were fabricated using carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) crosslinked with citric acid (CA) and glutaraldehyde (GA) at different concentrations. The crosslinker densities were optimized with various CA (2–10% w/v) and GA (1–5% v/v) concentrations. The optimized crosslink densities in the hydrogel exhibited additional functional group peaks in the FT-IR spectra at 1740 cm−1 for the C=O stretching of the ester linkage in CA and at 1060 cm−1 for the C-O-C stretching of the ether group in GA. Significantly, the internal porous structures of hydrogel composite films improved density, swelling capacities, solubility percentage reduction, and decreased water retention capacities with optimized crosslinker densities. Therefore, these hydrogel composite films were utilized as drug carriers for controlled drug release within 24 h during medical treatment. Moreover, the hydrogel films demonstrated increased triamcinolone acetonide (TAA) absorption with higher crosslinker density, resulting in delayed drug release and improved TAA efficiency in anti-inflammatory activity. As a result, the modified hydrogel showed the capability of being an alternative material with enhanced anti-inflammatory efficiency with hydrogel films.
