Nature Communications (Apr 2022)
Citrullination of glucokinase is linked to autoimmune diabetes
- Mei-Ling Yang,
- Sheryl Horstman,
- Renelle Gee,
- Perrin Guyer,
- TuKiet T. Lam,
- Jean Kanyo,
- Ana L. Perdigoto,
- Cate Speake,
- Carla J. Greenbaum,
- Aïsha Callebaut,
- Lut Overbergh,
- Richard G. Kibbey,
- Kevan C. Herold,
- Eddie A. James,
- Mark J. Mamula
Affiliations
- Mei-Ling Yang
- Section of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Yale University
- Sheryl Horstman
- Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
- Renelle Gee
- Section of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Yale University
- Perrin Guyer
- Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
- TuKiet T. Lam
- Department of Molecular Biophysics & Biochemistry, Yale University
- Jean Kanyo
- Keck MS & Proteomics Resource, WM Keck Foundation Biotechnology Resource Laboratory
- Ana L. Perdigoto
- Section of Endocrinology, Department of Internal Medicine, Yale University
- Cate Speake
- Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
- Carla J. Greenbaum
- Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
- Aïsha Callebaut
- Laboratory for Clinical and Experimental Endocrinology, KU Leuven
- Lut Overbergh
- Laboratory for Clinical and Experimental Endocrinology, KU Leuven
- Richard G. Kibbey
- Section of Endocrinology, Department of Internal Medicine, Yale University
- Kevan C. Herold
- Section of Endocrinology, Department of Internal Medicine, Yale University
- Eddie A. James
- Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
- Mark J. Mamula
- Section of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Yale University
- DOI
- https://doi.org/10.1038/s41467-022-29512-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Post translational modifications are involved in the regulation of a number of proteins and can be themselves modified by the cellular environment. Here the authors implicate citrullination of glucokinase in autoimmune diabetes
