Nature Communications (Jul 2020)

H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients

  • Kolja Schleich,
  • Julia Kase,
  • Jan R. Dörr,
  • Saskia Trescher,
  • Animesh Bhattacharya,
  • Yong Yu,
  • Elizabeth M. Wailes,
  • Dorothy N. Y. Fan,
  • Philipp Lohneis,
  • Maja Milanovic,
  • Andrea Lau,
  • Dido Lenze,
  • Michael Hummel,
  • Bjoern Chapuy,
  • Ulf Leser,
  • Maurice Reimann,
  • Soyoung Lee,
  • Clemens A. Schmitt

DOI
https://doi.org/10.1038/s41467-020-17467-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Therapy-induced senescence reflects a biological effector principle that is underrecognized in lesion-focused cancer precision medicine. Here the authors utilize mouse lymphoma genetics to functionally dissect senescence and cross-species apply a novel senescence-based prognosticator to lymphoma patients.