Nature Communications (Nov 2018)

Mediated nuclear import and export of TAZ and the underlying molecular requirements

  • Michael Kofler,
  • Pam Speight,
  • Darby Little,
  • Caterina Di Ciano-Oliveira,
  • Katalin Szászi,
  • András Kapus

DOI
https://doi.org/10.1038/s41467-018-07450-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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The transcriptional co-factors Yap and TAZ are regulated by Hippo signalling and mechanical forces via their nucleocytoplasmic shuttling. Here the authors identify a RhoA-regulated C-terminal nuclear localization signal and a TEAD-regulated N-terminal nuclear export signal of TAZ in an epithelial cell line.