Are Brazilian bamboo species helpful for cognition and memory?

Janayne Gagliano; Stefani Altenhofen; Débora Dreher Nabinger; Darlan Gusso; Julia Maria Kuhl-Silva; Fernanda Anselmo-Moreira; Lydia Fumiko Yamaguchi; Massuo Jorge Kato; Carla Denise Bonan; Cláudia Maria Furlan

Phytomedicine Plus (Feb 2022)

Are Brazilian bamboo species helpful for cognition and memory?

Janayne Gagliano,
Stefani Altenhofen,
Débora Dreher Nabinger,
Darlan Gusso,
Julia Maria Kuhl-Silva,
Fernanda Anselmo-Moreira,
Lydia Fumiko Yamaguchi,
Massuo Jorge Kato,
Carla Denise Bonan,
Cláudia Maria Furlan

Affiliations

Janayne Gagliano: Department of Botany, Institute of Bioscience, University of São Paulo, Brazil. Rua do Matão, 277, São Paulo, SP 05508-090, Brazil; Corresponding author at: Department of Botany, Institute of Bioscience, University of São Paulo, Brazil. Rua do Matão, 277, São Paulo, SP 05508-090, Brazil.
Stefani Altenhofen: Laboratório de Neuroquímica e Psicofarmacologia, Programa de Pós-Graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Brazil. Avenida Ipiranga 6681, Porto Alegre, RS 90619-900, Brazil
Débora Dreher Nabinger: Laboratório de Neuroquímica e Psicofarmacologia, Programa de Pós-Graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Brazil. Avenida Ipiranga 6681, Porto Alegre, RS 90619-900, Brazil
Darlan Gusso: Laboratório de Neuroquímica e Psicofarmacologia, Programa de Pós-Graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Brazil. Avenida Ipiranga 6681, Porto Alegre, RS 90619-900, Brazil
Julia Maria Kuhl-Silva: Laboratório de Neuroquímica e Psicofarmacologia, Programa de Pós-Graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Brazil. Avenida Ipiranga 6681, Porto Alegre, RS 90619-900, Brazil
Fernanda Anselmo-Moreira: Department of Botany, Institute of Bioscience, University of São Paulo, Brazil. Rua do Matão, 277, São Paulo, SP 05508-090, Brazil
Lydia Fumiko Yamaguchi: Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, Brazil. Avenida Professor Lineu Prestes, 748, São Paulo, SP 05508-000, Brazil
Massuo Jorge Kato: Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, Brazil. Avenida Professor Lineu Prestes, 748, São Paulo, SP 05508-000, Brazil
Carla Denise Bonan: Laboratório de Neuroquímica e Psicofarmacologia, Programa de Pós-Graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Brazil. Avenida Ipiranga 6681, Porto Alegre, RS 90619-900, Brazil
Cláudia Maria Furlan: Department of Botany, Institute of Bioscience, University of São Paulo, Brazil. Rua do Matão, 277, São Paulo, SP 05508-090, Brazil; Corresponding author at: Department of Botany, Institute of Bioscience, University of São Paulo, Brazil. Rua do Matão, 277, São Paulo, SP 05508-090, Brazil.

Journal volume & issue: Vol. 2, no. 1
p. 100183

Abstract

Read online

Background: Bamboo species has been used for centuries in Asian traditional medicine to treat mental disorders resulting from the aging process. Brazil has the greatest diversity of bamboos in the Americas, with a high degree of endemism, but just a few of them has been studied for bioprospecting purposes. Purpose: Considering the previous report on the use of Asian bamboos to treat diseases affecting cognition and memory, a set of Brazilian bamboos species was investigated for similar properties. Methods: Leaves from Olyra glaberrima, Parodiolyra micrantha, Aulonemia aristulata, Filgueirasia arenicola, Filgueirasia cannavieira, and Merostachys pluriflora were investigated to their chemical profiles, free radical scavenging, anticholinesterase properties, toxicological effects on zebrafish larvae (Danio rerio), and protective effect on memory impairment assays (scopolamine-induced assay). Results: Based on HPLC-ESI-MS/MS data, 70 compounds had their putative structures assigned based on analysis of molecular formula and fragmentation pattern. The most abundant compounds were glycosylated flavonoids, followed by terpenoids and soluble sugars. Overall bamboo leaf extracts showed high antioxidant potential. A moderate potential as an inhibitor of the acetylcholinesterase activity was detected for M. pluriflora. The in vivo assays indicated that aqueous extracts at 0.1 mg/ml are not toxic for zebrafish embryos and do not alter the larval exploratory behavior. The extracts from O. glaberrima, P. micrantha, A. aristulata, and F. arenicola increased the cognitive capacity of zebrafish larvae against an aversive stimulus. In adult zebrafish, the extracts from O. glaberrima, F. cannavieira, and M. pluriflora prevented the cognitive deficit induced by scopolamine treatment. Conclusions: Aqueous extracts of the six Brazilian bamboo species showed high in vitro antioxidant potential. Some bamboo extracts increased the cognitive capacity of zebrafish larvae in the face of an aversive stimulus. Furthermore, some of them can reduce the memory loss induced by scopolamine in zebrafish adults. Moreover, many substances that were detected in this study had never been described for bamboos. This was the first study with herbaceous bamboo species; it is also the first study that used zebrafish as an experimental model to test bamboo extracts.

Published in Phytomedicine Plus

ISSN: 2667-0313 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Other systems of medicine
Website: https://www.journals.elsevier.com/phytomedicine-plus/

About the journal

Abstract

Keywords