Nature Communications (Feb 2016)
Hypothalamic leptin action is mediated by histone deacetylase 5
- Dhiraj G. Kabra,
- Katrin Pfuhlmann,
- Cristina García-Cáceres,
- Sonja C. Schriever,
- Veronica Casquero García,
- Adam Fiseha Kebede,
- Esther Fuente-Martin,
- Chitrang Trivedi,
- Kristy Heppner,
- N. Henriette Uhlenhaut,
- Beata Legutko,
- Uma D. Kabra,
- Yuanqing Gao,
- Chun-Xia Yi,
- Carmelo Quarta,
- Christoffer Clemmensen,
- Brian Finan,
- Timo D. Müller,
- Carola W. Meyer,
- Marcelo Paez-Pereda,
- Kerstin Stemmer,
- Stephen C. Woods,
- Diego Perez-Tilve,
- Robert Schneider,
- Eric N. Olson,
- Matthias H. Tschöp,
- Paul T. Pfluger
Affiliations
- Dhiraj G. Kabra
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Katrin Pfuhlmann
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Cristina García-Cáceres
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Sonja C. Schriever
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Veronica Casquero García
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Adam Fiseha Kebede
- Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Université de Strasbourg
- Esther Fuente-Martin
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Chitrang Trivedi
- Department of Pharmacology & Toxicology, Zydus Research Centre, Cadila Healthcare Limited
- Kristy Heppner
- Division of Endocrinology, Department of Internal Medicine, Metabolic Diseases Institute, University of Cincinnati
- N. Henriette Uhlenhaut
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Beata Legutko
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Uma D. Kabra
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Yuanqing Gao
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Chun-Xia Yi
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Carmelo Quarta
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Christoffer Clemmensen
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Brian Finan
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Timo D. Müller
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Carola W. Meyer
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Marcelo Paez-Pereda
- Max Planck Institute of Psychiatry
- Kerstin Stemmer
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Stephen C. Woods
- Division of Endocrinology, Department of Internal Medicine, Metabolic Diseases Institute, University of Cincinnati
- Diego Perez-Tilve
- Division of Endocrinology, Department of Internal Medicine, Metabolic Diseases Institute, University of Cincinnati
- Robert Schneider
- Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Université de Strasbourg
- Eric N. Olson
- Department of Molecular Biology, UT Southwestern Medical Center
- Matthias H. Tschöp
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- Paul T. Pfluger
- Helmholtz Diabetes Center, Helmholtz Zentrum München
- DOI
- https://doi.org/10.1038/ncomms10782
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDAC5 regulates leptin sensitivity by deacetylating STAT3.
