Reductive cyanation of organic chlorides using CO2 and NH3 via Triphos–Ni(I) species

Yanan Dong; Peiju Yang; Shizhen Zhao; Yuehui Li

doi:10.1038/s41467-020-17939-2

Nature Communications (Aug 2020)

Reductive cyanation of organic chlorides using CO2 and NH3 via Triphos–Ni(I) species

Yanan Dong,
Peiju Yang,
Shizhen Zhao,
Yuehui Li

Affiliations

Yanan Dong: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Center for Excellence in Molecular Synthesis, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences
Peiju Yang: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Center for Excellence in Molecular Synthesis, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences
Shizhen Zhao: Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, School of Medicine, Henan University
Yuehui Li: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Center for Excellence in Molecular Synthesis, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-020-17939-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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Nitriles are key intermediates in production of pharmaceuticals, agrochemicals and organic materials. Here, the authors report a nickel-catalyzed reductive cyanation of organic chlorides with CO2/NH3 and urea as cyanation reagents to afford a broad range of organic nitriles.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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