Frontiers in Molecular Biosciences (Sep 2022)

Role of USP13 in physiology and diseases

  • Qian Wang,
  • Qian Wang,
  • Qian Wang,
  • Zhenzhen Sun,
  • Zhenzhen Sun,
  • Zhenzhen Sun,
  • Weiwei Xia,
  • Weiwei Xia,
  • Weiwei Xia,
  • Le Sun,
  • Le Sun,
  • Le Sun,
  • Yang Du,
  • Yang Du,
  • Yang Du,
  • Yue Zhang,
  • Yue Zhang,
  • Yue Zhang,
  • Zhanjun Jia,
  • Zhanjun Jia,
  • Zhanjun Jia

DOI
https://doi.org/10.3389/fmolb.2022.977122
Journal volume & issue
Vol. 9

Abstract

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Ubiquitin specific protease (USP)-13 is a deubiquitinase that removes ubiquitin from substrates to prevent protein degradation by the proteasome. Currently, the roles of USP13 in physiology and pathology have been reported. In physiology, USP13 is highly associated with cell cycle regulation, DNA damage repair, myoblast differentiation, quality control of the endoplasmic reticulum, and autophagy. In pathology, it has been reported that USP13 is important in the pathogenesis of infection, inflammation, idiopathic pulmonary fibrosis (IPF), neurodegenerative diseases, and cancers. This mini-review summarizes the most recent advances in USP13 studies involving its pathophysiological roles in different conditions and provides new insights into the prevention and treatment of relevant diseases, as well as further research on USP13.

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