Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina

Xiuxiang Lu; Xiuxiang Lu; Yanjiang Zhang; Yanjiang Zhang; Wenge Zhang; Wenge Zhang; Huan Wang; Huan Wang; Jun Zhang; Sasa Wang; Haibo Tan; Haibo Tan

doi:10.3389/fchem.2021.738307

Frontiers in Chemistry (Sep 2021)

Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina

Xiuxiang Lu,
Xiuxiang Lu,
Yanjiang Zhang,
Yanjiang Zhang,
Wenge Zhang,
Wenge Zhang,
Huan Wang,
Huan Wang,
Jun Zhang,
Sasa Wang,
Haibo Tan,
Haibo Tan

Affiliations

Xiuxiang Lu: Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
Xiuxiang Lu: University of Chinese Academy of Sciences, Beijing, China
Yanjiang Zhang: Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
Yanjiang Zhang: University of Chinese Academy of Sciences, Beijing, China
Wenge Zhang: Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
Wenge Zhang: University of Chinese Academy of Sciences, Beijing, China
Huan Wang: Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
Huan Wang: National Engineering Research Center of Navel Orange, Gannan Normal University, Ganzhou, China
Jun Zhang: National Engineering Research Center of Navel Orange, Gannan Normal University, Ganzhou, China
Sasa Wang: Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi University for Nationalities, Nanning, China
Haibo Tan: Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
Haibo Tan: National Engineering Research Center of Navel Orange, Gannan Normal University, Ganzhou, China

DOI: https://doi.org/10.3389/fchem.2021.738307
Journal volume & issue: Vol. 9

Abstract

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Chemical investigation of an endophytic fungus Diaporthe foeniculina SCBG-15, led to the isolation of eight new cyclohexanone derivatives, foeniculins A–H (1–8) and three new phenolic acid derivatives, foeniculins I–K (9–11). Their structures were extensively established on the basis of 1H and 13C NMR spectra together with COSY, HSQC, HMBC, and NOESY experiments. The absolute configurations were confirmed by quantum chemical ECD calculations and single-crystal X-ray diffractions. Moreover, the in vitro cytotoxic and antibacterial activities of isolated compounds 1–11 were also evaluated.

Published in Frontiers in Chemistry

ISSN: 2296-2646 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://journal.frontiersin.org/journal/chemistry

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