New generation of oxide-based nanoparticles for the applications in early cancer detection and diagnostics

Abstract

Hereby the possible applications of oxide nanoparticles in the cancer diagnostics and therapy are presented. Cancer diseases are nowadays one of the most common causes of death in the highly-developed countries. Discussed will be the current clinical cancer detection methods with their shortcomings. The role of nanomedicine in cancer medicine and the potential applications of nanoparticles debated in the literature will be critically evaluated. In the second part, the most common methods for the nanoparticle synthesis will be discussed. Finally, the system for cancer detection based on the enhanced permeation-retention of multimodal high-k oxide nanoparticles doped with lanthanides will be proposed for both for themagnetic resonance imaging (non-gadolinium contrast agents) and for fluorescence guided biopsy and surgery.

Keywords

• medical nanoparticles
• cancer diagnostics and therapy
• enhanced permeation and retention (epr)
• multimodal oxide nanoparticles
• lanthanides
• fluorescent contrast
• mri