Neurocognitive patterns across genetic levels in behavioral variant frontotemporal dementia: a multiple single cases study

Abstract

Highlights • Different genetic levels in underrepresented FTD patients are not well understood. • We compared cognition, neuropsychiatry, and gene-atrophy overlap in FTD cases. • Mutations (MAPT-TARDBP-TREM2), variants (tau-APOE) & sporadic cases were compared. • FTD genetic level was linked to clinical & neurocognitive changes in case analysis. • Mutations showed more impairments than risk variants and sporadic presentations.

Keywords

• MAPT
• TARDBP
• TREM2
• Tau haplotypes
• APOE variants
• bvFTD