DEVELOPMENT AND VALIDATION OF THE METHOD OF VITAMINE E DETERMINATION IN MICROEMULSION COMPOSITIONS BY HIGH-EFFECTIVE LIQUID CHROMATOGRAPHY

S. V. Kursakov; E. G. Kuznetsova; O. M. Kuryleva; L. A. Salomatina; V. I. Sevastianov

Разработка и регистрация лекарственных средств (Jan 2019)

DEVELOPMENT AND VALIDATION OF THE METHOD OF VITAMINE E DETERMINATION IN MICROEMULSION COMPOSITIONS BY HIGH-EFFECTIVE LIQUID CHROMATOGRAPHY

S. V. Kursakov,
E. G. Kuznetsova,
O. M. Kuryleva,
L. A. Salomatina,
V. I. Sevastianov

Affiliations

S. V. Kursakov: Academician V. I. Shumakov National Medical Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation; ANO «Institute of biomedical research and technology»
E. G. Kuznetsova: Academician V. I. Shumakov National Medical Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
O. M. Kuryleva: Academician V. I. Shumakov National Medical Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
L. A. Salomatina: Academician V. I. Shumakov National Medical Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
V. I. Sevastianov: Academician V. I. Shumakov National Medical Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation

Journal volume & issue: Vol. 0, no. 3
pp. 88 – 95

Abstract

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The results of development and validation of the method of vitamin E detrmination in microemulsion compositions suitable for its controlling in transdermal delivery systems and also for the incoming control of tocopherol acetate oil solutions presents in the article. The method is based on the vitamin E extraction from the microemulsion by a mixture of acetonitrile - ethyl acetate (80:20) and subsequent analysis by reversed-phase HPLC. The main validation characteristics of the method meet the eligibility criterias. The analytical area of the methodology was from 0.1 to 10.0 mg/g vitamin E concentration. The results of method approbation on transdermal delivery system laboratory samples on microemulsions based are presented.

Published in Разработка и регистрация лекарственных средств

ISSN: 2305-2066 (Print); 2658-5049 (Online)
Publisher: LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
Country of publisher: Russian Federation
LCC subjects: Social Sciences: Industries. Land use. Labor: Special industries and trades: Pharmaceutical industry
Website: https://www.pharmjournal.ru/

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