Chemotherapy-induced nausea and vomiting among cancer patients in Shanghai: a cross-sectional study

ZENG Cheng, JIN Yizi, LI Ting, ZHANG Zhen, LIANG Xiaohua, TANG Xi, LIU Tianshu, LI Qi, SHEN Zan, JIANG Bin, WANG Liwei, ZHANG Jun, CHEN Siyu, ZHOU Caicun, GAO Yong, ZANG Yuansheng, LI Hengyu, DONG Yuchao, ZHAN Xianbao, ZHONG Yi, LIU Lingshuang, QIN Yuenong, HU Xichun, ZHANG Jian

doi:10.19401/j.cnki.1007-3639.2023.11.006

Zhongguo aizheng zazhi (Nov 2023)

Chemotherapy-induced nausea and vomiting among cancer patients in Shanghai: a cross-sectional study

ZENG Cheng, JIN Yizi, LI Ting, ZHANG Zhen, LIANG Xiaohua, TANG Xi, LIU Tianshu, LI Qi, SHEN Zan, JIANG Bin, WANG Liwei, ZHANG Jun, CHEN Siyu, ZHOU Caicun, GAO Yong, ZANG Yuansheng, LI Hengyu, DONG Yuchao, ZHAN Xianbao, ZHONG Yi, LIU Lingshuang, QIN Yuenong, HU Xichun, ZHANG Jian

Affiliations

ZENG Cheng, JIN Yizi, LI Ting, ZHANG Zhen, LIANG Xiaohua, TANG Xi, LIU Tianshu, LI Qi, SHEN Zan, JIANG Bin, WANG Liwei, ZHANG Jun, CHEN Siyu, ZHOU Caicun, GAO Yong, ZANG Yuansheng, LI Hengyu, DONG Yuchao, ZHAN Xianbao, ZHONG Yi, LIU Lingshuang, QIN Yuenong, HU Xichun, ZHANG Jian: 1. Department of Medical Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;2. Phase Ⅰ Clinical Trial Center, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;3. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai Key Laboratory of Radiation Oncology, Shanghai Clinical Research Center for Radiation Oncology, Shanghai 200032, China;4. Department of Oncology, Huashan Hospital, Fudan University, Shanghai 200040, China;5. Department of Oncology, Huadong Hospital, Fudan University, Shanghai 200040, China;6. Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China;7. Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;8. Department of Oncology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China;9. Department of Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201999, China;10. Department of Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China;11. Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;12. Department of Oncology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China;13. Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China;14. Department of Oncology, Shanghai East Hospital, School of Medicine of Tongji University, Shanghai 200120, China;15. Department of Medical Oncology, The Second Affiliated Hospital of Naval Medical University, Shanghai 200070, China;16. Department of Throat and Breast, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China;17. Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China;18. Department of Oncology, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China;19. Department of Oncology, Shanghai TCM-integrated Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China;20. Department of Oncology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;21. Breast Department of Integrated Traditional Chinese and Western Medicine, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China

DOI: https://doi.org/10.19401/j.cnki.1007-3639.2023.11.006
Journal volume & issue: Vol. 33, no. 11
pp. 1009 – 1017

Abstract

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Background and purpose: Chemotherapy-induced nausea and vomiting (CINV) can cause severe damage to body functions and even lead to death. The prevention of CINV is critically important in patients receiving emetogenic chemotherapy regimen. This study aimed to investigate the prevalence and treatment of CINV in Grade-A tertiary hospitals in Shanghai and explore risk factors of CINV to improve its management. Methods: The clinical data of 376 cancer patients in Grade-A tertiary hospitals in Shanghai from October 2022 to December 2022 were collected retrospectively. The questionnaire was used to conduct a cross-sectional study. The univariate and multivariable logistic regression models were used to evaluate the influencing factors of CINV. Results: The management and coincidence of the guideline in 2022 significantly improved compared to five years ago. For patients receiving high-emetic-risk chemotherapy regimen, the coincidence of the guideline increased from 21.6% to 67.0%. For patients receiving moderate-emetic-risk chemotherapy regimen, the neurokinin-1 (NK-1) receptor antagonist was not significantly associated with CINV. Multivariable analysis showed that the chemotherapy regimen was the only risk factor for CINV during the whole period (P<0.05). Conclusion: The chemotherapy regimen is the main risk factor for CINV. To control CINV better, clinical practitioners should focus on the intrinsic risk of chemotherapy regimens preferentially, estimate the risk and adhere better to guidelines.

|chemotherapy-induced nausea and vomiting|cancer|cross-sectional study

Published in Zhongguo aizheng zazhi

ISSN: 1007-3639 (Print)
Publisher: Editorial Office of China Oncology
Country of publisher: China
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.china-oncology.com/EN/1007-3639/home.shtml

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