European Radiology Experimental (Apr 2020)
PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers
- Luis Martí-Bonmatí,
- Ángel Alberich-Bayarri,
- Ruth Ladenstein,
- Ignacio Blanquer,
- J. Damian Segrelles,
- Leonor Cerdá-Alberich,
- Polyxeni Gkontra,
- Barbara Hero,
- J. M. García-Aznar,
- Daniel Keim,
- Wolfgang Jentner,
- Karine Seymour,
- Ana Jiménez-Pastor,
- Ismael González-Valverde,
- Blanca Martínez de las Heras,
- Samira Essiaf,
- Dawn Walker,
- Michel Rochette,
- Marian Bubak,
- Jordi Mestres,
- Marco Viceconti,
- Gracia Martí-Besa,
- Adela Cañete,
- Paul Richmond,
- Kenneth Y. Wertheim,
- Tomasz Gubala,
- Marek Kasztelnik,
- Jan Meizner,
- Piotr Nowakowski,
- Salvador Gilpérez,
- Amelia Suárez,
- Mario Aznar,
- Giuliana Restante,
- Emanuele Neri
Affiliations
- Luis Martí-Bonmatí
- Medical Imaging Department, La Fe University and Polytechnic Hospital & Biomedical Imaging Research Group (GIBI230) at La Fe University and Polytechnic Hospital and Health Research Institute
- Ángel Alberich-Bayarri
- Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Edificio Europa
- Ruth Ladenstein
- Children’s Cancer Research Institute
- Ignacio Blanquer
- Instituto de Instrumentación para Imagen Molecular (I3M), Universitat Politècnica de València (UPV)
- J. Damian Segrelles
- Instituto de Instrumentación para Imagen Molecular (I3M), Universitat Politècnica de València (UPV)
- Leonor Cerdá-Alberich
- Biomedical Imaging Research Group (GIBI230), La Fe Health Research Institute
- Polyxeni Gkontra
- Biomedical Imaging Research Group (GIBI230), La Fe Health Research Institute
- Barbara Hero
- Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne
- J. M. García-Aznar
- Multiscale in Mechanical and Biological Engineering, Department of Mechanical Engineering, Universidad de Zaragoza
- Daniel Keim
- Department of Computer Science, University of Konstanz
- Wolfgang Jentner
- Department of Computer Science, University of Konstanz
- Karine Seymour
- Medexprim
- Ana Jiménez-Pastor
- Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Edificio Europa
- Ismael González-Valverde
- Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Edificio Europa
- Blanca Martínez de las Heras
- Paediatric Oncology Unit, La Fe University and Polytechnic Hospital
- Samira Essiaf
- European Society for Paediatric Oncology
- Dawn Walker
- Department of Computer Science and Insigneo Institute of In Silico Medicine, University of Sheffield
- Michel Rochette
- Simulation, Modelling and Engineering Software, Ansys Group
- Marian Bubak
- ACC Cyfronet, AGH University of Science and Technology, Sano Centre for Computational Medicine
- Jordi Mestres
- Chemotargets S.L.
- Marco Viceconti
- Department of Industrial Engineering, Alma Mater Studiorum, University of Bologna
- Gracia Martí-Besa
- Biomedical Imaging Research Group (GIBI230), La Fe Health Research Institute
- Adela Cañete
- Paediatric Oncology Unit, La Fe University and Polytechnic Hospital
- Paul Richmond
- Department of Computer Science and Insigneo Institute of In Silico Medicine, University of Sheffield
- Kenneth Y. Wertheim
- Department of Computer Science and Insigneo Institute of In Silico Medicine, University of Sheffield
- Tomasz Gubala
- ACC Cyfronet, AGH University of Science and Technology, Sano Centre for Computational Medicine
- Marek Kasztelnik
- ACC Cyfronet, AGH University of Science and Technology, Sano Centre for Computational Medicine
- Jan Meizner
- ACC Cyfronet, AGH University of Science and Technology, Sano Centre for Computational Medicine
- Piotr Nowakowski
- ACC Cyfronet, AGH University of Science and Technology, Sano Centre for Computational Medicine
- Salvador Gilpérez
- Matical Innovation
- Amelia Suárez
- Matical Innovation
- Mario Aznar
- Matical Innovation
- Giuliana Restante
- Department of Translational Research, University of Pisa, Chair Radiodiagnostica 3, Pisa University Hospital
- Emanuele Neri
- Department of Translational Research, University of Pisa, Chair Radiodiagnostica 3, Pisa University Hospital
- DOI
- https://doi.org/10.1186/s41747-020-00150-9
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 11
Abstract
Abstract PRIMAGE is one of the largest and more ambitious research projects dealing with medical imaging, artificial intelligence and cancer treatment in children. It is a 4-year European Commission-financed project that has 16 European partners in the consortium, including the European Society for Paediatric Oncology, two imaging biobanks, and three prominent European paediatric oncology units. The project is constructed as an observational in silico study involving high-quality anonymised datasets (imaging, clinical, molecular, and genetics) for the training and validation of machine learning and multiscale algorithms. The open cloud-based platform will offer precise clinical assistance for phenotyping (diagnosis), treatment allocation (prediction), and patient endpoints (prognosis), based on the use of imaging biomarkers, tumour growth simulation, advanced visualisation of confidence scores, and machine-learning approaches. The decision support prototype will be constructed and validated on two paediatric cancers: neuroblastoma and diffuse intrinsic pontine glioma. External validation will be performed on data recruited from independent collaborative centres. Final results will be available for the scientific community at the end of the project, and ready for translation to other malignant solid tumours.
Keywords
- Artificial intelligence
- Biomarkers (tumour)
- Cloud computing
- Diffuse intrinsic pontine glioma
- Neuroblastoma
