Nature Communications (Aug 2021)

Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylactics

  • Shaojuan Zhao,
  • Huajun Zhang,
  • Xinglou Yang,
  • Haiwei Zhang,
  • Ying Chen,
  • Yancheng Zhan,
  • Xiaoqing Zhang,
  • Rendi Jiang,
  • Meiqin Liu,
  • Lan Liu,
  • Li Chen,
  • Wei Tang,
  • Cheng Peng,
  • Xiaoxiao Gao,
  • Zhe Zhang,
  • Zhengli Shi,
  • Rui Gong

DOI
https://doi.org/10.1038/s41467-021-25153-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Applying neutralizing antibodies against SARS-CoV-2 to infected patients is a promising anti-viral treatment strategy. Here, Zhao et al. derive RBD-targeting monoclonal antibodies from a naïve human phage-displayed Fab library and show their prophylactic and therapeutic potential in hACE2-transgenic mice.