Nature Communications (May 2020)

A role for actin flexibility in thin filament-mediated contractile regulation and myopathy

  • Meera C. Viswanathan,
  • William Schmidt,
  • Peter Franz,
  • Michael J. Rynkiewicz,
  • Christopher S. Newhard,
  • Aditi Madan,
  • William Lehman,
  • Douglas M. Swank,
  • Matthias Preller,
  • Anthony Cammarato

DOI
https://doi.org/10.1038/s41467-020-15922-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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The α-cardiac actin M305L hypertrophic cardiomyopathy-causing mutation is located near residues that help confine tropomyosin to an inhibitory position along thin filaments. Here the authors assessed M305L actin in vivo, in vitro, and in silico to characterize emergent pathological properties and define the mechanistic basis of disease.