Nature Communications (Jul 2022)
Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria
- Fauzia K. Musasia,
- Irene N. Nkumama,
- Roland Frank,
- Victor Kipkemboi,
- Martin Schneider,
- Kennedy Mwai,
- Dennis O. Odera,
- Micha Rosenkranz,
- Kristin Fürle,
- Domitila Kimani,
- James Tuju,
- Patricia Njuguna,
- Mainga Hamaluba,
- Melissa C. Kapulu,
- Hedda Wardemann,
- CHMI-SIKA Study Team,
- Faith H. A. Osier
Affiliations
- Fauzia K. Musasia
- Centre for Infectious Diseases, Heidelberg University Hospital
- Irene N. Nkumama
- Centre for Infectious Diseases, Heidelberg University Hospital
- Roland Frank
- Centre for Infectious Diseases, Heidelberg University Hospital
- Victor Kipkemboi
- Centre for Infectious Diseases, Heidelberg University Hospital
- Martin Schneider
- Genomics and Proteomics Core Facility, German Cancer Research Center
- Kennedy Mwai
- Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme
- Dennis O. Odera
- Centre for Infectious Diseases, Heidelberg University Hospital
- Micha Rosenkranz
- Centre for Infectious Diseases, Heidelberg University Hospital
- Kristin Fürle
- Centre for Infectious Diseases, Heidelberg University Hospital
- Domitila Kimani
- Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme
- James Tuju
- Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme
- Patricia Njuguna
- Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme
- Mainga Hamaluba
- Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme
- Melissa C. Kapulu
- Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme
- Hedda Wardemann
- Division of B Cell Immunology, German Cancer Research Center
- CHMI-SIKA Study Team
- Faith H. A. Osier
- Centre for Infectious Diseases, Heidelberg University Hospital
- DOI
- https://doi.org/10.1038/s41467-022-31640-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Here the authors show that antibody-dependent phagocytosis of ring-stage P. falciparum parasites is mediated by merozoite antigens and is a strong predictor of protection following challenge in a controlled human malaria infection study in semi-immune Kenyan adults.
