Nature Communications (Dec 2018)
Metabolite changes in blood predict the onset of tuberculosis
- January Weiner,
- Jeroen Maertzdorf,
- Jayne S. Sutherland,
- Fergal J. Duffy,
- Ethan Thompson,
- Sara Suliman,
- Gayle McEwen,
- Bonnie Thiel,
- Shreemanta K. Parida,
- Joanna Zyla,
- Willem A. Hanekom,
- Robert P. Mohney,
- W. Henry Boom,
- Harriet Mayanja-Kizza,
- Rawleigh Howe,
- Hazel M. Dockrell,
- Tom H. M. Ottenhoff,
- Thomas J. Scriba,
- Daniel E. Zak,
- Gerhard Walzl,
- Stefan H. E. Kaufmann,
- The GC6-74 consortium
Affiliations
- January Weiner
- Max Planck Institute for Infection Biology
- Jeroen Maertzdorf
- Max Planck Institute for Infection Biology
- Jayne S. Sutherland
- Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Fergal J. Duffy
- The Center for Infectious Disease Research
- Ethan Thompson
- The Center for Infectious Disease Research
- Sara Suliman
- South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town
- Gayle McEwen
- Max Planck Institute for Infection Biology
- Bonnie Thiel
- Tuberculosis Research Unit, Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center
- Shreemanta K. Parida
- Max Planck Institute for Infection Biology
- Joanna Zyla
- Max Planck Institute for Infection Biology
- Willem A. Hanekom
- South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town
- Robert P. Mohney
- Metabolon Inc.
- W. Henry Boom
- Tuberculosis Research Unit, Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center
- Harriet Mayanja-Kizza
- Department of Medicine, School of Medicine, College of Health Sciences, Makerere University
- Rawleigh Howe
- Armauer Hansen Research Institute
- Hazel M. Dockrell
- Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine
- Tom H. M. Ottenhoff
- Department of Infectious Diseases, Leiden University Medical Centre
- Thomas J. Scriba
- South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town
- Daniel E. Zak
- The Center for Infectious Disease Research
- Gerhard Walzl
- NRF-DST Centre of Excellence for Biomedical TB Research and MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University
- Stefan H. E. Kaufmann
- Max Planck Institute for Infection Biology
- The GC6-74 consortium
- DOI
- https://doi.org/10.1038/s41467-018-07635-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
The tuberculosis pandemic requires new methods for diagnosing and containing infections prior to active disease. Here, the authors performed a multi-site observational study within sub-Saharan Africa and present serum and plasma metabolic signatures that can predict the onset of active TB with a high degree of sensitivity and specificity.
