Nutrients (Apr 2024)

Increased Depressive-like, Anxiety-like, and Perseverative-like Behavior in Binge Eating Model in Juvenile Rats

  • Alma Delia Genis-Mendoza,
  • Isela Esther Juárez-Rojop,
  • Yudy Merady Escobar-Chan,
  • Carlos Alfonso Tovilla-Zárate,
  • María Lilia López-Narváez,
  • Humberto Nicolini,
  • Thelma Beatriz González-Castro

DOI
https://doi.org/10.3390/nu16091275
Journal volume & issue
Vol. 16, no. 9
p. 1275

Abstract

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The aim of the present study was to evaluate depressive-like, anxiety-like, and perseverative-like behaviors in a binge eating model. Juvenile Wistar rats, using the binge eating model, were compared to caloric restriction, induced stress, and control groups. Rats of the induced stress group presented binge-like behaviors in standard food intake in the second cycle of the experiment when compared to the caloric restriction group and the binge eating model group. Depressive-like behavior was observed in the binge eating model group with longer immobility time (p p p = 0.04) and a longer duration of burying time when compared to the control group (p = 0.02). We observed perseverative-like behavior by the binge model group, who made more entries to the new arm (p = 0.0004) and spent a longer time in the new arm when compared to the control group (p = 0.0001). Our results show differences in behaviors between the groups of rats studied. These results suggest that calorie restriction–refeeding, along with stress, may lead to depressive-like, anxiety-like, and perseverative-like behavioral changes in male Wistar rats.

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