<b>2-Hydroxy-4-methoxybenzaldehyde: Larvicidal structure-activity studies</b>

Abstract

2-Hydroxy-4-methoxybenzaldehyde (1), a compound isolated from Mondia whytei (Hook) Skeels (Asclepiaceae) roots exhibited larvicidal activity (LD50 22 μg/mL). A total of 18 other derivatives and closely related congeners revealed varying levels of larvicidal activity. Several closely related congeners, like 2-benzyloxy-4-methoxybenzaldehyde (2), 2-hydroxybenzaldehyde (12), 2-benzyloxybenzaldehyde (3) and benzylphenyl ether (4), showed marked improvement in activity (LD50 10, 9, 4.8, 1.2 μg/mL, respectively) against Anopheles gambiae larvae. 2-Benzoyloxy-4-methoxybenzaldehyde (5) exhibited similar activity level (LD50 28 μg/mL) as 1.

Keywords

• 2-Hydroxy-4-methoxybenzaldehyde
• Larvicides
• Structure-activity relationships
• 2-Hdroxybenzaldehyde
• 2-Benzyloxybenzaldehyde
• Benzylphenyl ether <i>Anopheles gambiae</i>