Comparative study of dexmedetomidine versus midazolam infusion with local anesthesia for middle ear surgeries

Abstract

Background: Middle ear surgeries can be performed under local anesthesia, which is well tolerated when used with sedation. Objective: compare the effect of dexmedetomidine versus midazolam as a sedative in middle ear surgeries done under local anesthesia. Methods: 60 adult patients undergoing middle ear surgeries were randomly allocated into two groups, Group D (n=30) received inj Dexmedetomidine loading dose of 1 mcg/kg over 10 minutes followed by maintenance of 0.2 mcg/kg/hr. Group M received inj. midazolam loading dose of 0.03mg/kg over 10 minutes followed by maintenance of 0.02 mg/kg/hr. Parameters recorded were sedation, patient’s & surgeon’s satisfaction, pain, side effects. Results: Demographic data were comparable in both the groups. Mean RSS was 2.27±0.45 in group M and 2.90±0.31 in group D (P <0.001), significant. Mean VAS for pain was 2.24±0.9 and 1.36±0.6 in group M and group D respectively (P=0.001), significant. Patient’s and surgeon’s satisfaction were significant in group D, (P≤0.001) compared to group M. Side effects were minimal and treated effectively (P =0.212), statistically not-significant. Conclusion: Dexmedetomidine compared to midazolam found to be better drug with respect to sedation, analgesia, patient’s and surgeon’s satisfaction for middle ear surgeries done under local anesthesia.

Keywords

• dexmedetomidine
• midazolam
• middle ear surgeries