Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years

Jakob Hofvander; Björn Viklund; Anders Isaksson; Otte Brosjö; Fredrik Vult von Steyern; Pehr Rissler; Nils Mandahl; Fredrik Mertens

doi:10.1038/s41467-018-06098-0

Nature Communications (Sep 2018)

Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years

Jakob Hofvander,
Björn Viklund,
Anders Isaksson,
Otte Brosjö,
Fredrik Vult von Steyern,
Pehr Rissler,
Nils Mandahl,
Fredrik Mertens

Affiliations

Jakob Hofvander: Division of Clinical Genetics, Department of Laboratory Medicine, Lund University
Björn Viklund: Science for Life Laboratory, Department of Medical Sciences, Uppsala University
Anders Isaksson: Science for Life Laboratory, Department of Medical Sciences, Uppsala University
Otte Brosjö: Department of Orthopedics, Karolinska Hospital
Fredrik Vult von Steyern: Department of Orthopedics, Clinical Sciences, Lund University and Skåne University Hospital
Pehr Rissler: Department of Clinical Genetics and Pathology, University and Regional Laboratories Region Skåne
Nils Mandahl: Division of Clinical Genetics, Department of Laboratory Medicine, Lund University
Fredrik Mertens: Division of Clinical Genetics, Department of Laboratory Medicine, Lund University

DOI: https://doi.org/10.1038/s41467-018-06098-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 8

Abstract

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Hofvander and colleagues compare the patterns of clonal evolution in different pathogenetic subgroups of sarcoma. They show that sarcomas driven by gene fusion or amplification display few additional changes over time, whereas sarcomas with complex karyotypes show a gradual increase of nucleotide- and chromosome-level mutations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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