Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish

Anne Karine Lagendijk; Guillermo A. Gomez; Sungmin Baek; Daniel Hesselson; William E. Hughes; Scott Paterson; Daniel E. Conway; Heinz-Georg Belting; Markus Affolter; Kelly A. Smith; Martin A. Schwartz; Alpha S. Yap; Benjamin M. Hogan

doi:10.1038/s41467-017-01325-6

Nature Communications (Nov 2017)

Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish

Anne Karine Lagendijk,
Guillermo A. Gomez,
Sungmin Baek,
Daniel Hesselson,
William E. Hughes,
Scott Paterson,
Daniel E. Conway,
Heinz-Georg Belting,
Markus Affolter,
Kelly A. Smith,
Martin A. Schwartz,
Alpha S. Yap,
Benjamin M. Hogan

Affiliations

Anne Karine Lagendijk: Institute for Molecular Bioscience, Genomics of Development and Disease division, The University of Queensland
Guillermo A. Gomez: Institute for Molecular Bioscience, Cell Biology and Molecular Medicine division, The University of Queensland
Sungmin Baek: Institute for Molecular Bioscience, Genomics of Development and Disease division, The University of Queensland
Daniel Hesselson: Garvan Institute of Medical Research
William E. Hughes: Garvan Institute of Medical Research
Scott Paterson: Institute for Molecular Bioscience, Genomics of Development and Disease division, The University of Queensland
Daniel E. Conway: Department of Biomedical Engineering, Virginia Commonwealth University
Heinz-Georg Belting: Biozentrum der Universität Basel
Markus Affolter: Biozentrum der Universität Basel
Kelly A. Smith: Institute for Molecular Bioscience, Genomics of Development and Disease division, The University of Queensland
Martin A. Schwartz: Yale Cardiovascular Research Center and Department of Internal Medicine, Cardiovascular Medicine, Yale University School of Medicine
Alpha S. Yap: Institute for Molecular Bioscience, Cell Biology and Molecular Medicine division, The University of Queensland
Benjamin M. Hogan: Institute for Molecular Bioscience, Genomics of Development and Disease division, The University of Queensland

DOI: https://doi.org/10.1038/s41467-017-01325-6
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Mechanical forces play a crucial role during morphogenesis, but how these are sensed and transduced in vivo is not fully understood. Here the authors apply a FRET tension sensor to live zebrafish and study changes in VE-cadherin tension at endothelial cell-cell junctions during arterial maturation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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