Simplified Synthesis of Isotopically Labeled 5,5-Dimethyl-pyrroline N-Oxide

Abstract

5,5-Dimethylpyrroline N-oxide (15N) and 5,5-di(trideuteromethyl)pyrroline N-oxide were synthesized from the respective isotopically labeled 2-nitropropane analogs obtained from the reaction of sodium nitrate with 2-halopropanes. This facile, straightforward process allows synthesizing isotopically labeled DMPO analogs in a 4-step reaction without special equipment.

Keywords

• spin trap
• isotopic labeling
• DMPO