Silencing of NAMPT leads to up-regulation of insulin receptor substrate 1 gene expression in U87 glioma cells

Tsymbal Daria O.; Minchenko Dmytro O.; Luzina Olena Y.; Riabovol Olena O.; Danilovskyi Serhiy V.; Minchenko Oleksandr H.

doi:10.2478/enr-2020-0005

Endocrine Regulations (Jan 2020)

Silencing of NAMPT leads to up-regulation of insulin receptor substrate 1 gene expression in U87 glioma cells

Tsymbal Daria O.,
Minchenko Dmytro O.,
Luzina Olena Y.,
Riabovol Olena O.,
Danilovskyi Serhiy V.,
Minchenko Oleksandr H.

Affiliations

Tsymbal Daria O.: Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Minchenko Dmytro O.: Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Luzina Olena Y.: Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Riabovol Olena O.: Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Danilovskyi Serhiy V.: Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Minchenko Oleksandr H.: Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine

DOI: https://doi.org/10.2478/enr-2020-0005
Journal volume & issue: Vol. 54, no. 1
pp. 31 – 42

Abstract

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Objective. The aim of the present study was to investigate the effect of adipokine NAMPT (nicotinamide phosphoribosyltransferase) silencing on the expression of genes encoding IRS1 (insulin receptor substrate 1) and some other proliferation related proteins in U87 glioma cells for evaluation of the possible significance of this adipokine in intergenic interactions.

Published in Endocrine Regulations

ISSN: 1336-0329 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://sciendo.com/journal/ENR

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