Frontiers in Immunology (May 2022)

β-1,6-Glucan From Pleurotus eryngii Modulates the Immunity and Gut Microbiota

  • Xue Wang,
  • Yunhe Qu,
  • Yuan Wang,
  • Xiang Wang,
  • Jialei Xu,
  • Hailing Zhao,
  • Donglin Zheng,
  • Lin Sun,
  • Guihua Tai,
  • Yifa Zhou,
  • Hairong Cheng

DOI
https://doi.org/10.3389/fimmu.2022.859923
Journal volume & issue
Vol. 13

Abstract

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Polysaccharides from Pleurotus eryngii exhibit a variety of biological activities. Here, we obtained a homogeneous branched β-1,6-glucan (APEP-A-b) from the fruiting bodies of P. eryngii and investigated its effect on immunity and gut microbiota. Our results showed that APEP-A-b significantly increases splenic lymphocyte proliferation, NK cell activity and phagocytic capacity of peritoneal cavity phagocytes. Furthermore, we found that the proportion of CD4+ and CD8+ T cells in lamina propria are significantly increased upon APEP-A-b treatment. Additionally, APEP-A-b supplementation demonstrated pronounced changes in microbiota reflected in promotion of relative abundances of species in the Lachnospiraceae and Rikenellaceae families. Consistently, APEP-A-b significantly increased the concentration of acetic and butyric acid in cecum contents. Overall, our results suggest that β-1,6-glucan from P. eryngii might enhance immunity by modulating microbiota. These results are important for the processing and product development of P. eryngii derived polysaccharides.

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