Lnc‐GIHCG promotes cell proliferation and migration in gastric cancer through miR‐ 1281 adsorption

Abstract

Abstract Background Long noncoding RNAs (lncRNAs) are from the family of noncoding RNAs. Existing studies have shown that lncRNAs are involved in many biological processes and are strongly related to the occurrence and development of tumors. Recent studies have indicated that lncRNA GIHCG participates in the progression of many cancers by adjusting cell proliferation and migration. Gastric cancer (GC) is a prevalent malignant tumor that arises from gastric epithelium. This study mainly explored the influence of GIHCG on GC and its underlying mechanism. Methods GIHCG expression was detected in GC through quantitative real‐time polymerase chain reaction while the relationship of GIHCG with miR‐1281 and miR‐1281 with TLE1 was verified using dual luciferase reporter gene assay. The influence of GIHCG, miR‐1281 and TLE1 on cell function was verified using cell counting Kit‐8 (CCK‐8) and Transwell experiment. Results In GC, GIHCG was significantly overexpressed and significantly increased cell proliferation and migration, with the possible mechanism of upregulatingTLE1 expression through adsorption of miR‐1281. Conclusion Taken together, we revealed the role of GIHCG/miR‐1281/TLE1 in GC and provided a new perspective.

Keywords

• gastric cancer
• GIHCG
• lncRNAs
• mR‐1281
• TLE1